Now available for lease is approximately 8,240 square feet of second-generation medical office space within Roseland Medical Center, a purpose-built medical and neighborhood commercial campus located at 100-134 W 111th Street, Chicago, Illinois. Constructed in 2007, the property was intentionally designed to support long-term healthcare occupancy and remains one of the most established medical destinations in the Roseland submarket. The available space is situated within a professionally managed, elevator-served building and was previously configured as a multi-specialty medical clinic, allowing an incoming healthcare user to significantly reduce build-out time and upfront capital expenditures. The layout and infrastructure are well suited for outpatient medical, primary care, specialty care, dental, behavioral health, diagnostic, or community health uses, subject to zoning and municipal approvals. The property is zoned C1-1 (Neighborhood Commercial District), which supports a broad range of medical and professional service uses. A defining characteristic of Roseland Medical Center is its direct location across the street from Roseland Community Hospital, a full-service hospital that serves as a major healthcare anchor for the surrounding area. This immediate hospital adjacency provides consistent daily activity, visibility, and functional synergy that is highly sought after by outpatient and specialty providers. The campus was developed as a one-stop healthcare environment, creating a natural ecosystem for patient referrals, continuity of care, and operational efficiency. The property benefits from on-site parking, ADA-compliant access, and strong frontage along West 111th Street, a primary east-west corridor serving the South Side of Chicago. Regional accessibility is excellent, with convenient connections to I-57 and I-94, supporting access for patients, staff, and service providers throughout the broader Chicago area. From a market perspective, second-generation medical office space of this scale and quality has become increasingly scarce, particularly in urban infill locations where new medical construction faces higher costs, longer timelines, and regulatory complexity. As healthcare delivery continues to shift toward outpatient and community-based settings, hospital-adjacent medical office campuses remain among the most resilient and sought-after real estate formats. This offering is well positioned for local, regional, and national medical tenants evaluating Chicago medical office space for lease with strong fundamentals, healthcare adjacency, and immediate functionality.